Pycnogenol®
(Powerful Natural Antioxidant Tablets)


Pycnogenol® is considered as a safe and natural powerful antioxidant and is widely used as a natural health product in the world. It is one of the main products of Hankintatukku-the leading Natural Health Products Company in Finland.

Description 

Chemistry of Pycnogenol

Pharmacological and Physiological Activities of Pycnogenol

Clinical Experience of Pycnogenol

Toxicology of Pycnogenol

Dosage

Pycnogenol® (20 mg Pycnogenol/tablet)
2-4 tablets a day
Pycnogenol Strongl® (40 mg Pycnogenol/tablet)
1-2 tablets a day

Package

Pycnogenol® (20 mg Pycnogenol/tablet)
60 tablets /18g
Pycnogenol Strongl® (40 mg Pycnogenol/tablet)
60 tablets/18g

References

  1. Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol).
    Grimm T et al.
    J Inflamm (Lond). 2006 Jan 27;3(1):1 [Epub ahead of print]
  2. Venous ulcers: microcirculatory improvement and faster healing with local use of pycnogenol((r)).
    Belcaro G, et al.
    Angiology. 2005 Nov-Dec;56(6):699-705.
  3. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol).
    Schafer A, et al
    Biomed Pharmacother. 2005 Oct 26; [Epub ahead of print]
  4. Prevention of edema in long flights with Pycnogenol
    Cesarone MR et al.
    Clin Appl Thromb Hemost. 2005 Jul;11(3):289-94.
  5. Pycnogenol as an adjunct in the management of childhood asthma.
    Lau BH, Riesen SK, Truong KP, Lau EW, Rohdewald P, Barreta RA.
    J Asthma. 2004;41(8):825-32.
  6. Pycnogenol((R)) accelerates wound healing and reduces scar formation.
    Blazso G, Gabor M, Schonlau F, Rohdewald P.
    Phytother Res. 2004 Jul;18(7):579-81.
  7. The effect of Pycnogenol on the erythrocyte membrane fluidity.
    Sivonova M, Waczulikova I, Kilanczyk E, Hrnciarova M, Bryszewska M, Klajnert B, Durackova Z.
    Gen Physiol Biophys. 2004 Mar;23(1):39-51.
  8. Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (pycnogenol).
    Grimm T, Schafer A, Hogger P.
    Free Radic Biol Med. 2004 Mar 15;36(6):811-22.
  9. Protection from inflammation, immunosuppression and carcinogenesis induced by UV radiation in mice by topical Pycnogenol.
    Sime S, Reeve VE.
    Photochem Photobiol. 2004 Feb;79(2):193-8.
  10. Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients.
    Liu X, Wei J, Tan F, Zhou S, Wurthwein G, Rohdewald P.
    Life Sci. 2004 Jan 2;74(7):855-62.
  11. Sharma SC, Sharma S, Gulati OP.
    Pycnogenol inhibits the release of histamine from mast cells.
    Phytother Res. 2003 Jan;17(1):66-9.
  12. Devaraj S, Vega-Lopez S, Kaul N, Schonlau F, Rohdewald P, Jialal I.
    Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile.
    Lipids. 2002 Oct;37(10):931-4.
  13. Hosseini S, Pishnamazi S, Sadrzadeh SM, Farid F, Farid R, Watson RR.
    Pycnogenol in the Management of Asthma.
    J Med Food. 2001 Winter;4(4):201-209.
  14. Schonlau F, Rohdewald P.
    Pycnogenol for diabetic retinopathy. A review.
    Int Ophthalmol. 2001;24(3):161-71.
  15. Ni Z, Mu Y, Gulati O.
    Treatment of melasma with Pycnogenol.
    Phytother Res 2002 Sep;16(6):567-71
  16. Roseff SJ.
    Improvement in sperm quality and function with French maritime pine tree bark extract.
    J Reprod Med 2002 Oct;47(10):821-4
  17. Feng WH, Wei HL, Liu GT.
    Effect of PYCNOGENOL on the toxicity of heart, bone marrow and immune organs as induced by antitumor drugs.
    Phytomedicine 2002 Jul;9(5):414-8
  18. Rohdewald P.
    A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology.
    Int J Clin Pharmacol Ther 2002 Apr;40(4):158-68
  19. Koch R.
    Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency.
    Phytother Res 2002 Mar;16 Suppl 1:S1-5
  20. Spadea L, Balestrazzi E.
    Treatment of vascular retinopathies with Pycnogenol.
    Phytother Res 2001 May;15(3):219-23
  21. Araghi-Niknam M, Hosseini S, Larson D, Rohdewald P, Watson RR
    Pine bark extract reduces platelet aggregation.
    Integr. Med. 2000 Mar 21;2(2):73-77
  22. Hasegawa N
    Inhibition of lipogenesis by pycnogenol
    Phytother Res 2000 Sep;14(6):472-3
  23. Hasegawa N
    Stimulation of lipolysis by pycnogenol.
    Phytother Res 1999 Nov;13(7):619-20
  24. Huynh HT, Teel RW
    Selective induction of apoptosis in human mammary cancer cells (MCF-7) by pycnogenol.
    Anticancer Res 2000 Jul-Aug;20(4):2417-20
  25. Packer L, Rimbach G, Virgili F
    Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol.
    Free Radic Biol Med 1999 Sep;27(5-6):704-24
  26. Liu FJ, Zhang YX, Lau BH
    Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice.
    Cell Mol Life Sci 1998 Oct 54:10 1168-72
  27. Petrassi C, Mastromarino A, Spartera C
    PYCNOGENOL in chronic venous insufficiency
    Phytomedicine 2000 Oct;7(5):383-8

(References searched and cited from National Library of Medicine-PubMed at http://www.ncbi.nlm.nih.gov/PubMed/ )

 This site edited and maintained by Yu Heci

The information provided on this site is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician.

Updated August 16, 2006

Copyright©  1998-2006

Hankintatukku Natural Health Products Co.
Museokatu 13 B, FIN-00100, Helsinki, FINLAND


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