New data about the effects of oral physiological magnesium supplementation on several cardiovascular
risk factors (lipids and blood pressure).
Kisters K, Spieker C, Tepel M, Zidek W
Magnes Res 1993 Dec 6:4 355-60

Abstract
In the present study the effect of oral physiological magnesium supplementation on atherogenic risk factors such as serum lipids and
blood pressure was examined. Sixty-nine patients with hyperlipidaemia of Frederickson types IV and IIb were investigated with
regard to renal function, blood pressure, serum cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol, and plasma and
erythrocytic magnesium concentrations. All patients were on cholesterol-poor (< 90 mg cholesterol/d) and energy-restricted diet (<
1200 kcal/d). Thirty-seven patients received 500 mg magnesium (oral) daily as a supplement. All measurements were performed
before and four weeks after starting treatment. The results of our study show that oral physiological magnesium supplementation in
addition to the usual dietary measures can be beneficial with regard to serum triglycerides (values, means +/- SD, decreased from
198.17 +/- 47.01 to 163.20 +/- 40.55 mg/dl, P < 0.05), but exerts no positive effect on blood pressure or serum cholesterol.
Furthermore, erythrocyte magnesium concentration increased significantly during oral physiological magnesium supplementation
(values, means +/- SD, increased from 1.72 +/- 0.22 to 1.91 +/- 0.18 mmol/litre, P < 0.05), whereas plasma magnesium
concentrations did not change significantly.