COLONIC Plus^® PROBIOTICS
(Viable LA-5 and BB-12 Bacterial Capsules)

Description

COLONIC Plus^® PROBIOTICS is a food supplement containing viable Lactobacillus (LA-5^TM)  and Bifidobacterium (BB-12^TM).

Lactobacillus, and Bifidobacteria and some other microbes are naturally present in the dominant colonic microbiota. For example Bifidobacteria represent up to 25% of the cultivable faecal bacteria in adults and 80% in infants.

Lactobacillus, and Bifidobacteria and some other microbes have been proposed as and used as probiotic strains, i.e. live microorganisms as food supplement in order to benefit health.

COLONIC Plus^® PROBIOTICS capsules have been manufactured by a unique process that ensures the probiotics in capsules to survive passage through the stomach and into the small intestine.

Ingredients of COLONIC Plus^® PROBIOTICS capsule:

per capsule cotains a minimum of 4 billion viable bacteria (Lactobacillus (LA-5^TM)  and Bifidobacterium (BB-12^TM)) at time of manufacture.

gelatin (capsule shell), glucose, potato starch

Magnesium srearate (E470b), Microcrystalline cellulose (E460), Color E171 (capsule shell)

free of lactose, yeast, gluten and any sweetener.

Package : 50 capsules /12 g

Storage: at room temperature, tightly closed.

Dosage: To maintain  and restore intestinal microbial balance : 1-3 capsules daily, taken with meals with a glass of water. During antibiotic treatment: 2-3 capsules daily taken 3 hours after antibiotic intake and continuing for 1 week.

Usage

• As probiotic agents, bifidobacteria have been studied for their efficacy in the prevention and treatment of a broad spectrum of animal and/or human gastrointestinal disorders, such as colonic transit disorders, intestinal infections, and colonic adenomas and cancer.

• The traditional use of bifidobacteria in fermented dairy products and the GRAS ('Generally Recognised As Safe') status of certain strains attest to their safety. Some strains show high gastrointestinal survival capacity and exhibit probiotic properties in the colon. Bifidobacteria are able to prevent or alleviate infectious diarrhoea through their effects on the immune system and resistance to colonization by pathogens. There is some experimental evidence that certain bifidobacteria may actually protect the host from carcinogenic activity of intestinal flora. Bifidobacteria may exert protective intestinal actions through various mechanisms, and represent promising advances in the fields of prophylaxis and therapy.

• Recent experimental studies and results from randomized controlled trials have shown that certain gut bacteria, in particular species of Lactobacillus and Bifidobacterium, may exert beneficial effects in the oral cavity by inhibiting cariogenic streptococci and Candida sp. Probiotics have been successfully used to control gastro-intestinal diseases. They also appear to alleviate symptoms of allergy and diseases with immunological pathology.
• The mechanisms of probiotic action appear to link with colonization resistance and immune modulation. Lactic acid bacteria can produce different antimicrobial components such as organic acids, hydrogen peroxide, carbon peroxide, diacetyl, low molecular weight antimicrobial substances, bacteriocins, and adhesion inhibitors, which also affect body microflora.

References

1. Ljungh A, Wadstrom T.
   Lactic acid bacteria as probiotics.
   Curr Issues Intest Microbiol. 2006 Sep;7(2):73-89.
2.  Riedel CU, et al.
   Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-kappaB activation.
    World J Gastroenterol. 2006 Jun 21;12(23):3729-35 
3. Marteau P.
   Living drugs for gastrointestinal diseases: the case for probiotics.
   Dig Dis. 2006;24(1-2):137-47.
4. Camilleri M.
   Probiotics and irritable bowel syndrome: rationale, putative mechanisms, and evidence of clinical efficacy.
   J Clin Gastroenterol. 2006 Mar;40(3):264-9
5. Gotteland M, et al.
   Systematic review: are probiotics useful in controlling gastric colonization by Helicobacter pylori?
   Aliment Pharmacol Ther. 2006 Apr 15;23(8):1077-86
6. Review article: bifidobacteria as probiotic agents -- physiological effects and clinical benefits.
   Picard C, et al.
   Aliment Pharmacol Ther. 2005 Sep 15;22(6):495-512
7. Meurman JH .
   Probiotics: do they have a role in oral medicine and dentistry?
   Eur J Oral Sci. 2005 Jun;113(3):188-96.