KOLESTOP^®  (Plant sterols tablets)

• Although plant sterols (phytosterols) and cholesterol have similar chemical structures, they differ markedly in their synthesis, intestinal absorption, and metabolic fate. Phytosterols inhibit intestinal cholesterol absorption, thereby lowering plasma total and low-density lipoprotein (LDL) cholesterol levels.
• Dietary phytosterols have been shown to lower plasma lipid concentrations in animals and humans.
• Phytosterols, abundant in fat-soluble fractions of plants, are easily destroyed when food is produced industrially.
• KOLESTOP^® contains beta-sitosterol and beta-sitostanol in abundance.
• KOLESTOP^® might be a useful hypolipidemic agent for the treatment of mild hypercholesterolemia.
• Daily dosage (6 tablets) contains 2000 mg of plant sterols, of which
  beta-sitosterol 1527 mg
  beta-sitostanol 473 mg

  Dosage:

  3 tablets 2 times a day. Tablets can be chewed before swallowing.

  Package:

  60 tablets / 31 g

  SITOSAN containing higher amount of beta-sitosterol is also available.

Usage

• Studies show dietary phytosterols reduce serum cholesterol by inhibiting cholesterol absorption and are effective in lowering serum total cholesterol and LDL cholesterol in subjects with mild hypercholesterolemia.
• A natural way to avoid risks caused by high cholesterol values.
• Addition to diet of the  sitostanol represents an effective means of improving circulating lipid profiles to reduce risk of coronary heart disease.
• Significant improvement in urological symptoms and urinary flow parameters also show the effectiveness of beta-sitosterol in the treatment of benign prostatic hyperplasia. Recent clinical trial has shown that in the treatment of symptomatic benign prostatic hyperplasia with beta-sitosterol, beneficial effects of beta-sitosterol treatment recorded in the 6-month double-blind trial were maintained for 18 months.

References

1. Moruisi KG, Oosthuizen W, Opperman AM.  
   Phytosterols/stanols lower cholesterol concentrations in familial hypercholesterolemic subjects: a systematic review with meta-analysis.
   J Am Coll Nutr. 2006 Feb;25(1):41-8.
2. Comparison of efficacy of plant stanol ester and sterol ester: short-term and longer-term studies.
   O'Neill FH et al.
   Am J Cardiol. 2005 Jul 4;96(1A):29D-36D.
3. Non-nutritive bioactive constituents of plants: phytosterols.
   Miettinen TA, Gylling H.
   Int J Vitam Nutr Res. 2003 Mar;73(2):127-34.
4. The beneficial effects of plant sterols on serum cholesterol.
   Wong NC.
   Can J Cardiol 2001 Jun;17(6):715-21
5. Effects of plant sterols and stanols on lipid metabolism and cardiovascular risk.
   Plat J, Mensink RP.
   Nutr Metab Cardiovasc Dis 2001 Feb;11(1):31-40
6. Plant sterols and their derivatives: the current spread of results.
   Jones PJ, Raeini-Sarjaz M.
   Nutr Rev 2001 Jan;59(1 Pt 1):21-4
7. Monograph. Plant sterols and sterolins.
   
   Altern Med Rev 2001 Apr;6(2):203-6
8. Treatment of symptomatic benign prostatic hyperplasia with beta-sitosterol: an 18-month follow-up.
   Berges RR, Kassen A, Senge T
   BJU Int 2000 May;85(7):842-6
9. Soy sterol esters and beta-sitostanol ester as inhibitors of cholesterol absorption in human small bowel.
   Normen L, Dutta P, Lia A, Andersson H
   Am J Clin Nutr 2000 Apr;71(4):908-13
10. Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men.
    Jones PJ, Ntanios FY, Raeini-Sarjaz M, Vanstone CA
    Am J Clin Nutr 1999 Jun 69:6 1144-50
11. P. J. Jones et al.
    Dietary phytosterols as cholesterol-lowering agents in humans
    Can. J. Physiol. Pharmacol. 75, 217-227 (1997)
12. H. Gylling
    Cholesterol absorption and lipoprotein metabolism in type II diabetes mellitus with and without coronary artery disease
    Atherosclerosis 126, 325-332 (1996)
    
13. T. Heinemann
    Effect of low-dose sitostanol on cholesterol in patients with hypercholesterolemia
    Atherosclerosis 61, 219-223 (1986)
    
14. A comparison of hypocholesterolemic activity of beta-sitosterol and beta-sitostanol in rats.
    Sugano M, Morioka H, Ikeda I.
    J Nutr 1977 Nov;107(11):2011-9
15. Antihypercholesterolemic activity of beta-sitostanol in rabbits.
    Ikeda I, Kawasaki A, Samezima K, Sugano M.
    J Nutr Sci Vitaminol (Tokyo) 1981;27(3):243-51
16. Effect of beta-sitostanol (5 alpha-stigmastan-3 beta-ol) on cholesterol absorption from micellar solutions in jejunal loops in situ.
    Hassan AS, Rampone AJ.
    Steroids 1980 Dec;36(6):731-41